Extending the Potency and Lifespan of Antibiotics: Inhibitors of Gram-Negative Bacterial Efflux Pumps

  26 April 2024

Efflux, a natural process in all cells, is a key resistance mechanism for multidrug-resistant bacteria. Chemical inhibition of efflux pumps has been a promising approach for antimicrobial chemotherapy. Over 50 efflux inhibitors target these systems, but none have been clinically used due to formulation, toxicity, and pharmacokinetic issues. Recent computational tools and molecular docking models offer hope for further research on efflux inhibitors, potentially serving as a platform for new bacterial efflux inhibitors.

Further reading: ACS Infectious Diseases
Author(s): Maëlle Duffey et al
Smart Innovations  
Back

OUR UNDERWRITERS

Unrestricted financial support by:

Antimicrobial Resistance Fighter Coalition

Bangalore Bioinnovation Centre

INTERNATIONAL FEDERATION PHARMACEUTICAL MANUFACTURERS & ASSOCIATIONS

BD





AMR NEWS

Every two weeks in your inbox

Because there should be one newsletter that brings together all One Health news related to antimicrobial resistance: AMR NEWS!

Subscribe

What is going on with AMR?
Stay tuned with remarkable global AMR news and developments!

Keep me informed